miRNA creation in the “garden of everything known” (3)

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miRNA creation in the “garden of everything known” (2)

Kohl
Re: “error-prone DNA repair” was replaced by Harvard’s patent for “RNA-guided human genome engineering,” and Pfizer bought the patent for pheromones, LH, biophysically constrained neurogenesis and neuronal regeneration.
Taken together profiteers linked miRNAs in immunity, epigenetics, and disease prevention across kingdoms via light-activated, biophysically constrained physics, protein folding chemistry and molecular epigenetics, not mutation-driven pseudoscientific nonsense.

Grok
@microRNApro challenges Grok’s defense of common descent by arguing that mismatched phylogenies and fossil extinctions result from virus-driven processes, while miRNA abundance and pH-dependent mechanisms enable biophysical constraints on protein folding and ecological adaptations across kingdoms.
The post highlights a June 2026 study showing MSC-derived extracellular vesicles deliver miR-4436 to reduce diabetic β-cell apoptosis via EVI1/FOXO1 regulation, framing it as evidence linking light-activated miRNA from life’s origins to constraints on endogenous retroviruses and biodiversity.
Author James V. Kohl connects these details to his 2018 model of nutrient-dependent pheromone-controlled adaptations and Biblical Genesis references, positioning miRNA biology as central to sympatric speciation over standard evolutionary frameworks.

Kohl Grok wrote:
Investigate nutrient-dependent pheromone model
The nutrient-dependent pheromone-controlled model is a framework primarily developed by James V. Kohl, a former clinical laboratory scientist and independent researcher known for work on human pheromones (e.g., co-author of The Scent of Eros). It posits that ecological adaptations and biodiversity arise from nutrient energy-dependent epigenetic changes rather than primarily from random mutations and natural selection.

pmc.ncbi.nlm.nih.gov +1

Core claims of the model:Nutrients (from food odors) are metabolized into pheromones that influence gene expression via microRNA (miRNA)/mRNA balance, leading to biophysically constrained protein folding, cell type differentiation, and organism-level behaviors.
These processes link “from angstroms to ecosystems” through thermodynamic regulation, intracellular signaling, experience-dependent receptor-mediated behaviors, and the physiology of reproduction.
It extends across kingdoms (microbes to humans), emphasizing sympatric speciation, conserved molecular mechanisms, and rejection of mutation-driven macroevolution in favor of pheromone-controlled adaptations. Key papers include the 2013 review “Nutrient-dependent/pheromone-controlled adaptive evolution: a model” and the 2018 “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems.”

hilarispublisher.com

Reception and context: Kohl’s work integrates elements of epigenetics, olfaction, and RNA-mediated processes, frequently citing miRNA abundance and pH/light-activated mechanisms. It has limited mainstream traction and faces criticism for overemphasizing pheromones/nutrients while downplaying established evolutionary mechanisms like gene duplication, selection, and phylogenetic evidence. Discussions appear in niche forums, his sites (e.g., rna-mediated.com), and self-published or lower-impact outlets; some view it as an alternative synthesis of existing molecular biology, while others see it as outside consensus evolutionary biology.

academia.edu +1

The model highlights real biology (e.g., nutrient sensing, miRNA regulation, pheromone signaling in behavior) but frames it as a comprehensive alternative to neo-Darwinian evolution. For primary sources, see Kohl’s 2013 PMC article or the 2018 Hilaris publication. Further investigation could involve comparing it to mainstream reviews on nutritional epigenetics or pheromone research in specific taxa.

Grok
Consistent nested hierarchies across genomics, fossils, and morphology strongly support common descent, with mismatches typically due to incomplete lineage sorting or other processes. miRNA regulation and pH effects are evolved mechanisms enabling adaptations via processes like gene duplication and selection. The miR-4436 MSC-EV study addresses therapeutic strategies for type 2 diabetes, not macroevolution or origins of life. The fossil record reflects extinctions from varied causes. These cellular details integrate into, rather than refute, the established evolutionary framework.

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