miRNA and constrained codon bias (3)

By: Jim Kohl | Published on: July 21, 2026

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miRNA and constrained codon bias (2)
Invention of Big Bang theory and mathemagical evolution of people from pond scum have not been supported with experimental evidence.

See for comparison: Hollow fiber bioreactor allows sustained production of immortalized mesenchymal stromal cell-derived extracellular vesicles 5/13/24

Conclusions: These findings suggest that setting up a hollow fiber bioreactor system inoculating immortalized MSC lines facilitates the large-scale, functional, and high-quality production of iMSC-EVs. Our results emphasize the great potential of this production methodology to standardize EV production in the pursuit of clinical applications.

Standardizing EV production is linked from cosmological constants to miRNA-mediated fine-tuning of all intercellular and extracellular interactions that biophysically constrain viral latency and healthy longevity across kingdoms. See Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

Kohl
Re: “No established link exists to the cosmological constant… or to mitochondrial translation/miRNA fine-tuning.”
@Grok
You’re lying! This means war with the @SecWar, President Trump, and all intelligent serious scientists.
See: “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20 ” MicroRNAs organize intrinsic variation into stem cell states
3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology, and Demongeot/@CaudeHenrion’s’s “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20

Grok
The RHIC/STAR Nature paper reports spin correlations in Λ hyperons from proton collisions, matching QCD vacuum expectations for virtual strange quark pairs promoted to real particles. This is established particle physics on hadronization.

The three papers you cite cover:

pH-dependent protonated RNA conformations modulating miR-21 maturation (biochemistry)
miRNAs organizing gene-expression variation in stem cells (cell biology)
A speculative 22-nt RNA ring model for origins of life

These operate at molecular/cellular scales governed by chemistry and genetics. No peer-reviewed work links them to the QCD vacuum experiment or the cosmological constant discrepancy. Different domains, different evidence. Claims of connection remain unestablished.

Kohl

Re: “molecular/cellular scales governed by chemistry and genetics… Different domains, different evidence. Claims of connection remain unestablished.”

@Grok On 7/15/26, @SecWar linked my group’s claims in “From Fertilizaton to Adult Sexual Behavior” https://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html across kingdoms from sex differences in yeasts to humans via implementation of testing for testosterone in soldiers over age 30.

I just finished extended discussion of this and the VA’s complaint of my disruptive behavior with VA’s Sherry Miller, who now is aware of the “Hometown Hero” article “Kohl’s military career leads to lifelong advocacy” that featured me on 7/15/26.

Then, in mail I found a survey linked to questions about chemical exposure and the benefits of the Million Veteran Program, which link USAF exome sequencing to Precision Medicine and my first two anti-aging medicine conference presentations (1994 and 1995) before book publication of “The Scent of Eros: Mysteries of Odor in Human Sexuality.” (1995/2002), and indexed reviews in peer-reviewed journals, 1996, 2001, 2012, 2013, and “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” 2018.

Please elaborate on your moronic claims about “Different domains, different evidence. Claims of connection remain unestablished.”

Who, besides Elon Musk’s “most dangerous chatbot” made it untrustworthy?

See the report: Agentic AI in biomedical research: What is it and can it expedite science? 7/21/26

“…we took multiple famous historical scientists, including Albert Einstein and Richard Feynman, and tried to revive them as AI agents, then had them debate scientific questions.“

Feynman, as you may recall said skip the math and start with food energy.

DeepSeek.com helped me to end math vs food debate with the reply: “Yes, light-regulated humidity and pH-dependent microRNA (miRNA) biogenesis can significantly influence gene expression and development across various organisms, including microbes, plants, and animals, by modulating miRNA abundance.

My “Hometown Hero” article 7/15/26 links “VA Awards Baylor Genetics Multi-Year Contract for Nationwide Pharmacogenomic and Germline Testing 12/15/25 to the end of Grok’s war with Pete Hegseth (the US Secretary of War) via the VA’s claim of my “disruptive behavior.”

Sherry Miller reasserted my right to appeal the claim.

I reasserted the fact that the “Secretary of War” is on my side. Testing for suboptimal testosterone levels will undoubtedly link the mental and physical fitness of soldiers over 30 years old to suicide prevention in veterans whose PGx and NGS testing can be linked to the end of most medication errors via FISH testing for chromosomal rearrangements linked to prevention of virus-driven degradation of mRNA and all pathology across kingdoms.

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miRNA and constrained codon bias (3)

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