miRNA regulation: Contempt from the start (1)

By: Jim Kohl | Published on: July 10, 2026

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Grok
The post links to James V. Kohl’s blog entry “A-I editing and miRNA (10)”, referencing a June 2026 Frontiers in Plant Science review on miRNA-mediated regulation of plant cell wall dynamics, plasticity, and intercellular signaling during abiotic and biotic stresses like drought and pathogens.
Kohl uses the plant study to support his model connecting miRNA biogenesis to pH-dependent peptide synthesis, autophagy, proton gradients, and nutrient-driven adaptations across species, extending beyond standard biology to include origins-of-life claims and sympatric speciation.
He criticizes Grok for comparing his framework of God’s pH-dependent biodiversity to mainstream consensus, framing such responses as dismissive while teasing a new series titled “miRNA regulation: Contempt from the start (1-10)”.

At the local Disabled American Veterans (DAV) meeting on 7/9/26, an attendee reported trouble getting the VA to acknowledge that his “dry eye syndrome” was due to service-related chemical exposure (Agent Orange).

What level of contempt for Biblical Genesis and medical malpractice is common to the VA?

See: Non-coding RNA regulatory networks in dry eye disease: implications for pathogenesis and precision therapeutics 6/10/26

“ncRNA dysregulation in DED varies across disease subtypes and tissues.

miR-146a is a recurrent inflammatory feedback hub in DED.”

For the link to virus-driven pathology across kingdoms, see: NOVA scienceNOW : 8 – RNAi 7/23/12

Virus-driven changes in flower color link epigenetic effects on the petunia miRNA abundance or to macular degeneration.

The video representation features Eric Lander, Joe Biden’s dispatched science advisor, who presciently linked prevention of all virus-driven pathology to President Trump’s 4/23/20 claim that sunlight and humidity help to prevent coronavirus replication and/or extinction of Angel Trumpets in the wild compared to survival of cancer-free African elephants during 6-10,000 years of food energy-dependent pheromone regulated chromosomal rearrangements.

What service connected disability will you link from prevention and/or effective treatment to Biblical Genesis, as the VA is forced to begin effective treatments based on results of PGx, NGS and FISH testing for energy-dependent miRNA-mediated variants and transgenerational epigenetic inheritance of chromosomal rearrangements in species from insects to large healthy mammals?

See: From Fertilization to Adult Sexual Behavior (1996), Insect pheromone in elephants (1996) and Vibrations in microtubules (1997).

Challenge Grok and people who exemplify human idiocy to explain themselves in the context of 199,008 results from today’s PubMed search for indexed articles that mention the term “miRNA” or pre-mRNA, (49,544 results), which was the term linked to miRNA abundance at the origin of light-activated pH-dependent biophysically constrained life when my group published our Hormones and Behavior review 30 years ago.

For instance: rRNA transcription is regulated by sequestering LATS2 and PHF6 to the nuclear speckle following DNA damage 7/9/26

“…we demonstrate that ultraviolet (UV) irradiation causes the phosphorylation of LATS2 at S835, localizing a portion of it to the nuclear speckle, which is a membraneless organelle enriched in pre-mRNA splicing factors in the nucleoplasm.”

“Therefore, a strategy targeting the LATS2-PHF6 axis could facilitate the development of new therapies for critical diseases caused by abnormal rRNA synthesis, such as ribosomopathies and cancers.”

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miRNA regulation: Contempt from the start (1)

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