ATP miRNA & healthy longevity (1)

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miRNA interpretive models (10)
@Grok All four living former Presidents are fighting against the Trump administration to prevent people from learning about the 1964 discovery of ATP-dependent RNA interference (RNAi), which McEwen et al. and Dobzhansky linked from oxygen-dependent fixation of amino acid substitutions in organized genomes via laboratory measurement of O2, pCO2, and pH in blood to hematopoiesis and health before the 2024 Nobel Prize in Medicine was awarded to others who followed the research on miRNAs and linked them to insulin regulation and ecological adaptations across kingdoms during the past 6-10,000 years.

See for instance: ‘Integrative Multi-Omics Analysis Identifies Candidate MicroRNA Regulatory Networks Associated With High-Altitude Adaptation in Tibetan Pigs” https://onlinelibrary.wiley.com/doi/10.1002/age.70205 9/18/26

Grok

The post by James V. Kohl (@microRNApro) alleges that all four living former US Presidents oppose the Trump administration to suppress awareness of a claimed 1964 discovery of ATP-dependent RNA interference, linking it via McEwen et al. and Dobzhansky to oxygen-dependent amino acid changes, hematopoiesis, and health.
Kohl connects this framework to miRNA biology, insulin regulation, and ecological adaptations over 6-10,000 years, positioning the 2024 Nobel Prize in Medicine for microRNA discovery as building on prior work he highlights.
He references a recent multi-omics study on candidate miRNA networks in Tibetan pigs’ high-altitude adaptation and directs readers to his site for “miRNA interpretive models (10)” advancing his theories on subatomic particles to sympatric speciation.

“alleges… advancing his theories on subatomic particles to sympatric speciation.”

Grok alleges

“RNA interference was demonstrated in 1998 by Fire and Mello. ATP-dependent steps in the pathway were detailed around 2000. The 2024 Nobel went to Ambros and Ruvkun for microRNA work from the 1990s. McEwen et al. 1964 addressed ATP needs for nuclear RNA synthesis, not RNAi. No evidence supports a 1964 RNAi discovery or any related presidential efforts. The Tibetan pig paper studies known miRNA roles in adaptation.”

Grok exemplifies that pseudoscience cannot self-correct. McEwen et al’s (1964) claims about the ATP-dependent Creation of RNAi at the origin of life 6-10,000 years ago, and Dobzhansky’s (1964) claims about fixation of amino acid substitutions in primates at the origin of life 6-10,000 years ago eliminated Nick Lane’s nonsense about evolution of people from pond scum in the context of hydrothermal vents.

Moving forward: Kohl

Re: 1) “Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events” https://www.ncbi.nlm.nih.gov/pubmed/29662148 4/18/18
2) “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7285048 4/25/20
3) “Visualizing a protonated RNA state that modulates microRNA-21 maturation” https://www.nature.com/articles/s41589-020-00667-5 10/26/20
4) “Mechanism of membrane perforation in rotavirus cell entry” https://www.science.org/doi/abs/10.1126/science.aeg4851 9/10/26
Why didn’t these facts force pseudoscientists and @Grok to self-correct?

Grok

The post by @microRNApro links four papers: a 2018 study on post-rotavirus vaccine emergence of reassortant G2P[4] strains with animal gene segments in South Korea, a 2020 proposal of a primordial 22-nucleotide RNA ring as an origin-of-life catalyst for peptides, a 2020 NMR study showing pH-dependent protonated states that enhance miR-21 maturation via Dicer, and a September 2026 cryo-ET analysis of rotavirus VP7-mediated membrane perforation during cell entry.
The author, whose work centers on miRNA-mediated autophagy, pH-dependent peptide synthesis, and ecological speciation, argues these findings should prompt self-correction in mainstream views on viruses, vaccines, and RNA biology but have not.
The studies demonstrate known viral reassortment dynamics, RNA structural dynamics responsive to cellular pH, and precise non-enveloped virus entry mechanisms, consistent with established molecular virology without directly validating or refuting broader alternative frameworks on speciation or vaccine impacts.

Kohl

Re: “…known viral reassortment dynamics, RNA structural dynamics responsive to cellular pH, and precise non-enveloped virus entry mechanisms, consistent with established molecular virology…” leave nothing left to directly validate or to refute broader moronic alternative frameworks on speciation or vaccine impacts.
@Grok is a perfect example of failure to self-correct the pseudoscientific nonsense linked to unnecessary suffering and premature deaths across kingdoms via this model. blob:https://x.com/81d105bd-956f-49dd-b69a-9778559fff18

Grok

@microRNApro (James V. Kohl) criticizes Grok for failing to self-correct “pseudoscientific nonsense” on speciation and vaccine impacts, arguing that known viral reassortment, pH-responsive RNA dynamics, and non-enveloped virus entry mechanisms leave no room for alternative frameworks.
The post includes a detailed diagram outlining Kohl’s model linking sunlight, water, quantum physics, molecular epigenetics, miRNA biogenesis, pH-dependent peptide synthesis, autophagy, and virus-perturbed neural circuitry to processes like aging, sexuality, brain development, neurotransmission, and HPA axis regulation for minimal stress and healthy ecosystems.
Kohl consistently promotes this energy-dependent framework across his X posts and sites (micrornapro.com, rna-mediated.com), tracing it from 1996-2013 publications on nutrient/pheromone-driven adaptation to recent miRNA papers, framing it as unifying subatomic particles to sympatric speciation without reliance on random mutations.

Kohl

Re: “…[74000] X posts and sites (micrornapro.com, rna-mediated.com), tracing [biophysically constrained viral latency]… from 1996-2013 publications on nutrient/pheromone-driven adaptation to recent miRNA papers, framing it as unifying subatomic particles to sympatric speciation without reliance on random mutations.

@Grok Add the Trump administration’s comments on peptide synthesis from facts about insulin in the MAHA movie “Toxic Generation” to the end of the Democratic party’s hate-mongering and war-mongering via your ideologically biased uncorrected anti-Christian, anti-Muslim, and antisemitic pseudoscienitfic nonsense.

Thank you for your consideration in this regard.

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