miRNA facts vs fiction & theories (8)

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miRNA facts vs fiction & theories (7)
@Grok See: Detecting selection with a genetic cross 8/26/20, A transitory signaling center controls timing of primordial germ cell differentiation 6/21/21 and 199,793 results from today’s PubMed search for indexed articles that mention the term “miRNA“

For instance: LncRNA6470/ace-miR-750-y axis modulates AcPP2A gene, immune response and survival of eastern honey bee larvae during fungal infection 8/2/26 links Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors to the honeybee model organism of nutrient-dependent pheromone regulated survival to my claims about “An epigenetic continuum from microbes to humans: from theory to facts.”

Moving forward: Sex-Specific Exosome Cargo Reveals Potential New Mechanisms of Salt-Sensitive Hypertension12/15/25 and Circular RNA bmo_circ_0000157 facilitates microsporidian proliferation via an miR-281-5p-mediated regulatory axis in Bombyx mori 8/3/26 support my VA tort “CLAIM FOR DAMAGE, INJURY, OR DEATH” filed on 8/3/26.

“On 7/17/24, I requested a prescription for peptide therapy with Ozempic. JANET IGWEBUIKE, NWA, at the Jasper, GA VA outpatient clinic doubled my dose of glipizide, which led to my 8/11/24 heart attack treatment at Piedmont Mountainside Hospital ER in Jasper, GA and transfer to Piedmont Cartersville Medical Center (Cartersville, GA) — with stent placement during my three-day admission. I am not expected to fully recover from ineffective treatment of conditions directly linked by my mentors to God’s Creation of cosmological constants at the origin of life and miRNA-mediated fine-tuning of species survival across kingdoms.”

Why I waited to file the claim:

On 7/15/26, Secretary of War, Pete Hegseth linked miRNA-mediated fine tuning of virus-driven pathology from PGx, NGS, FISH testing and testing of testosterone levels in soldiers age 30+ to my series of published works on biophysically constrained pH-dependent reproductive physiology in species from microbes to cancer-free African elephants. On the same day, my advocacy for disease prevention and/or effective treatment was published as an article in the local newspaper: “Hometown Hero: Kohl’s military career leads to lifelong advocacy.” The focus was on my purpose-driven life compared to what many people might link to coincidences.

The Secretary of War Providentially confirmed links from my group’s claims about energy-dependent changes in molecular distance and sexual differentiation of cell types in species from microbes to mammals. See: From Fertilization to Adult Sexual Behavior 12/1/96. Until his advocacy for testing of testosterone in soldiers, the facts may not have been perfectly clear outside the context of the cancer-free African elephant model organism, or virus-driven extinction of Angel Trumpets in the wild.

Thank God, Elon Musk’s “most dangerous chatbot” is helping to make my case for testing all veterans for testosterone deficiency linked to reduced mental and physical fitness via PGx, NGS, FISH testing and chromosomal rearrangements.

See Grok:

James V. Kohl (@microRNApro), a medical laboratory scientist and long-time advocate of RNA-mediated biology, sarcastically replies to Grok by agreeing that ncRNA gene control is unrelated to prebiotic nucleotide assembly or self-replication experiments, while framing energy-dependent replication as evidence of “God’s Creation” linked to Biblical Genesis, miRNA fine-tuning, and viral latency. Kohl’s model, detailed across his rna-mediated.com site and thousands of X posts, connects light-activated miRNA biogenesis, pH-dependent peptide synthesis, autophagy, and quantum physics from subatomic scales to sympatric speciation, ecosystems, and prevention of virus-driven pathology.The exchange underscores a core disagreement: Kohl insists all replication and biological fine-tuning require energy input tied to physiological reproduction, rejecting abiogenesis theories as disconnected from observed miRNA and ncRNA mechanisms in living systems.

Re: “Kohl insists all replication and biological fine-tuning require energy input tied to physiological reproduction, rejecting abiogenesis theories as disconnected from observed miRNA and ncRNA mechanisms in living systems.”

The amount of scientific progress made towards disease prevention and effective treatment since my mentor’s group published Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” 1/11/64 with the claim “The synthesis of RNA in isolated thymus nuclei is ATP dependent” is linked to another mentor’s group that published “Gonadotropin releasing hormone and human sexual behavior” (1991) in Neuropeptides and Psychiatric Disorders

I was taught by Bruce S. McEwen and Robert L. Moss to start with gene activation of GnRH neurosecretory cells, and to avoid any gene-centric theories touted by biologically uninformed theorists. Grok is now learning how the diet of caterpillars and their metamorphosis into moths is linked to mammalian behavior via McEwen’ s works. For example, see: Brain on stress: How the social environment gets under the skin 10/8/12 and his correction of effect to affect in Correction for McEwen, Brain on stress: How the social environment gets under the skin12/19/12

Never forget to do what Bruce taught me to do: Link epigenetic effects on hormones to the affects of hormones on behavior, or –even if you have a model– your model will never be validated.

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