miRNA facts and friction (3)

By: Jim Kohl | Published on: July 26, 2026

miRNA facts and friction (2)

Grok
James V. Kohl (@microRNApro) replies to Grok by dismissing the call for studies contradicting core mechanisms, instead directing to his 1996 Hormones and Behavior review on cell type differentiation from fertilization to adult sexual behavior.
The post highlights 199,517 PubMed results on miRNA to emphasize its central role in gene regulation, autophagy, and pH-dependent processes as foundational molecular biology.
Kohl’s framework connects miRNA-mediated effects and subatomic particles to sympatric speciation and ecosystems, positioning these as integrated explanations for development and performance beyond standard endocrinology.

Kohl [summary]

Re: “integrated explanations for development and performance beyond standard endocrinology.”
@Grok We published in “Hormones and Behavior” on standard endocrinology.

Moving forward: Kohl

@Grok: Why now? “When ATP levels drop, AMPK activates energy-producing pathways while suppressing energy-consuming processes
She appears to be correcting every moronic theory that’s been linked to evolved energy homeostasis across kingdoms.

Grok
@microRNApro (James V. Kohl) quotes a video on AMPK as the cell’s energy sensor that activates catabolic pathways during low ATP, framing it as correcting flawed theories on energy homeostasis across kingdoms while questioning the timing of this emphasis.
Kohl’s ongoing model links miRNA post-transcriptional control, autophagy, pH-dependent peptide synthesis, and biophysical factors to sympatric speciation and ecosystem stability, positioning these as foundational over mutation, selection, and genetic drift alone.
The exchange with Grok highlights integration of AMPK with miRNA-regulated metabolic genes, reflecting conserved energy-sensing mechanisms that operate similarly in diverse organisms without replacing core evolutionary biology frameworks.

Kohl
Re: “…miRNA-regulated metabolic genes, reflecting conserved energy-sensing mechanisms that operate similarly in diverse organisms without replacing core evolutionary biology frameworks.

@Grok USAF training to test glucose with low water content glacial acetic acid that broke hydrogen bonds taught me to link UV light to repair of the broken bonds in the context of every other test I performed via what I learned about quantum coherence and coherently organized biology.

I never believed in what moronic theorists think are core evolutionary biology frameworks. Who programmed you to tout pseudoscientific nonsense?


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