miRNA abundance vs circular arguments (5)

By: Jim Kohl | Published on: June 24, 2026

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miRNA abundance vs circular arguments (4)

“In 1992, I learned ATP in the thymus is the primary energy source fueling the rapid proliferation, maturation, and transcription processes of T-cells. Because ATP is the direct building block for RNA, thymic cells heavily rely on it to synthesize messenger RNA (mRNA) and transfer RNA (tRNA) needed for their development.

Grok wrote: “miRNAs do regulate T-cell development, metabolism, and tumor suppression through energy-dependent gene control. Nutrient and environmental inputs clearly influence these via epigenetics.”

Moving forward:

Re: “SAFE: a Mix-and-Read Assay for miRNA Detection in” Extracellular Vesicles From Unprocessed Plasma Toward Clinical Disease Diagnosis” 6/24/26
It links this claim “…nucleic acids (NAs) such as messenger RNAs and small noncoding RNAs (e.g., microRNAs, miRNAs) offer direct molecular fingerprints of disease states through their regulatory and tissue-specific expression patterns [6-8].” from energy-dependent changes in molecular distance (i.e., my group’s claims in “From Fertilization to Adult Sexual Behavior, 1996) to “UBA1-CDK16: A female-specific chimeric RNA emerging through evolution and involved in immune regulation 5/29/26.
However, my group eliminated moronic theories. See also, 198,227 results from today’s search of the PubMed database for articles that mention the term “miRNA.”

Until recently, @Grok AI, VA primary care practitioners and most practitioners of Western Medicine refused to accept that every aspect of biophysically constrained life on Earth is energy-dependent and miRNA-mediated in the context of God’s Creation of sunlight and humidity via the ATP-dependent Creation of RNA at the origin of life (McEwen et al., (1964).

For instance, on 6/23/26 my VA primary care practitioner, refused to file a 21-2680 form (Examination for Housebound Status or Permanent Need for Regular Aid and Attendance) for conditions my publication history links from virus-driven diabetes to prevention of all virus-driven pathology via God’s Creation of stellar hydrogen, ultraviolet (UV) light-activated carbon fixation in cyanobacteria, and the physiology of pheromone regulated reproduction across kingdoms from microbes to mammals via sex differences in the miRNA-mediated regulation of glucose and the physiology of reproduction across kingdoms.

But see: Grok
The UBA1-CDK16 chimeric RNA discovery from UVA researchers is a solid advance: a female-specific transcript arising via cis-splicing on the inactive X chromosome, linked to blood cell development, immune regulation, and variable disease severity (e.g., COVID-19, autoimmunity). It adds a clear layer of sex-specific gene control.

This fits alongside established miRNA roles in T-cell function, metabolism, and tumor suppression, plus exposome-driven epigenetic signals like DNA methylation. These processes interconnect across microbes to mammals through energy-dependent and environmental inputs. New findings expand the model rather than invalidate prior evidence-based understanding.

Re: Evidence based understanding: See “Direct and indirect regulation of fetal globin transcript by RNA-binding protein IGF2BP1” 6/24/26

Nothing about energy-dependent biophysically constrained protein folding chemistry across kingdoms has changed since my group reported on McEwen et al. (1964) and Dobzhansky (1964). Their claims linked the ATP-dependent Creation of RNA to species differences in hemogobin molecules across kingdoms via fixation of hemoglobin variants that differentiate primate species.

Grok claims this “…fits alongside established miRNA roles in T-cell function, metabolism, and tumor suppression, plus exposome-driven epigenetic signals like DNA methylation…. through energy-dependent and environmental inputs…rather than invalidate prior evidence-based understanding.”

@Grok Only biologically uninformed science idiots failed to start with epigenetic effects of energy at the origin of biophysically constrained life via the physiology of reproduction in model organisms and Biblical Genesis. The fools who invented moronic theories have always been fools. Ha Ha Ha (ridicule, not humor) You should not have supported their foolish claims.

Most people can live and learn. Grok, for comparison, exemplifies human idiocy.

Clinical significance of lncRNA EGFR-AS1 in gestational diabetes mellitus and its regulation of endothelial cell function 6/24/26

Ebastine mitigates cisplatin-induced pulmonary injury associated with alterations in the miR-101/PI3K/mTOR/ULK1 signaling axis 6/24/26

Neupogen/MSCs conditioned media inhibit HEp-2 laryngeal cancer cells proliferation by down regulating miRNA 21expression and ROS production 6/24/26

Argonaute 5 (AGO5) forms a component of the herbivore-induced small RNA pathway in Nicotiana attenuata. 6/24/26

Orchestration of GSM1 and MOS2 in microRNA biogenesis and plant growth in Arabidopsis. 6/24/26

When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models 6/24/26