miRNA abundance tunes cosmological constants (7)

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miRNA abundance tunes cosmological constants (6) See for comparison: Dynamics-enhanced molecular property prediction guided by deep learning 7/16/26
This was reported on 7/18/26: “By integrating molecular dynamics with deep learning, the authors demonstrate a scalable route toward more accurate predictions of toxicity, binding, and other molecular properties, bringing computational models closer to the dynamic reality of chemistry and biology”
Does it end the pseudoscientific nonsense touted by moronic theorists, exemplified by @Grok and regurgitated by Marco Antonio?

Grok

The X post by James V. Kohl (@microRNApro) links to his blog arguing that miRNA abundance, driven by energy-dependent nutrient intake, epigenetically tunes biological processes he equates to “cosmological constants” including DNA methylation and gene regulation.
It compares this to a July 2026 preprint on dynamics-enhanced molecular property prediction, which integrates molecular dynamics simulations with deep learning to improve accuracy in forecasting toxicity, binding affinity, and other properties beyond static molecular structures.
Kohl uses the paper to challenge what he calls pseudoscientific theories, specifically citing AI responses from @Grok and comments by Marco Antonio as examples of ignoring miRNA-mediated mechanisms in favor of abstract evolutionary or cosmic emergence models.

Moving forward:

Integrative methylation and miRNA dysregulation in dlPFC reveal distinct molecular signatures of suicide and non-suicide subtypes in major depressive disorder 5/28/26 links God’s Creation of cosmological constants to miRNA-mediated fine tuning of virus-driven pathology via ncRNA-driven regulation of PD-L1 in breast cancer: mechanisms of immune escape and therapeutic opportunities 7/19/26

My group’s claims in From Fertilization to Adult Sexual Behavior (1996) were linked to Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018) via God’s Creation of sunlight and humidity at the origin of life 6-10,000 years ago in Biblical Genesis and claims from Williams Textbook of Endocrinology (1992).

“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH.” (p. 1164)

Food energy-dependent pheromone regulated epigenetic effects on GnRH link link cosmological constants to miRNA-mediated fine tuning of all biodiversity on Earth. However, in context of moronic theories compared to ecological adaptations, this question arose: To eat or to breathe? 7/9/26

“…whereas the expression of detoxification genes that are not regulated by AHR [spermidine/ spermine N1-acetyl transferase 1 (Sat1) and catechol-O-methyltransferase (Comt)] increased with altitude. Trade-offs between modulation of the hypoxia response and detoxification might explain the feeding behaviors observed in other high-altitude mammals. Pikas, for example, avoid dietary toxins by storing plants until the toxins decay or by consuming preprocessed food items low in toxins, such as yak feces (14, 15). Alternatively, detoxification enzymes could mitigate oxidative stress associated with hypoxia (12, 13). More research is needed to understand the interactions between these pathways and to uncover the range of adaptations, beyond increased thermogenic capacity, that enable this remarkable animal to live at such a high altitude.

Your choice of what to believe requires knowledge linked to eating yak feces by Pikas, or knowledge of how light-activated nutrient-dependent pheromone regulated miRNA-mediated fine tuning of cosmological constants links energy-dependent COMT Val158Met variants to behavior across kingdoms via the physiology of reproduction in Biblical Genesis and Brain-derived neurotrophic factor (BDNF), a vital protein that acts as “Miracle-Gro for the brain”. It promotes the survival, growth, and maintenance of neurons. Crucially, it facilitates neuroplasticity, allowing your brain to form new neural connections, adapt to new information, and store memories.

Remember the claim “Eat feces and die” for comparison to Darwin’s “conditions of life,” 20 copies of p53 in cancer-free African elephants and extinction in the wild of virus-infected Angel Trumpets in my “Garden of Everything Known.”

See also: ‘Victimhood!’ GOP lawmaker loses it at disabled veterans in profane tirade and Hegseth’s Creepy Testosterone Obsession

“Doesn’t he have more important things to take care of, other than this stupid PR stunt? This is why he wants to exclude women from the miliary” (sic).

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