miRNA regulation: Contempt from the start (2)

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miRNA regulation: Contempt from the start (1)

Challenge @Grok and people who exemplify human idiocy to explain themselves in the context of 199,008 results from today’s PubMed search for indexed articles that mention the term “miRNA” or pre-mRNA (49,544 results), which was the term linked to miRNA abundance at the origin of light-activated pH-dependent biophysically constrained life when my group published our Hormones and Behavior review 30 years ago. For instance: rRNA transcription is regulated by sequestering LATS2 and PHF6 to the nuclear speckle following DNA damage 7/9/26

How is energy-dependent RNA-mediated DNA repair linked to moronic theories?

Moving forward, see: Kohl
Re: “Pangenome-based human genome analysis improves trait association and genomic prediction” https://pubmed.ncbi.nlm.nih.gov/42427655 7/3/26 indexed 7//10/26

[“…results suggest that integration of pangenomic methods into human genetic studies will improve trait association and genomic prediction at a meaningful subset of genes.”]

@Grok “miRNA-mediated regulation…explains prior GWAS results based on flanking SNPs [and] improved the performance of gene expression prediction models…”
Bruce McEwen told me to start with gene expression. Jerome Hui reported it, and Elizabeth Pennisi linked his claims to all biodiversity in “All in the (bigger) family” 1/16/15

Hui “found that in both insects and crustaceans, the same set of micro RNAs [miRNAs] control expression of the genes for those enzymes.” The extension of facts to “Insect pheromone in elephants” (1996) appeared before my group linked them “From Fertilization to Adult Sexual Behavior” (1996) in species from yeasts to cancer-free African elephants.

Grok
The X post by @microRNApro links a July 2026 pangenome preprint to [energy-dependent] miRNA regulation, noting how it captures structural variants like GBAP1 pseudogene copy number to explain Crohn’s GWAS signals via miRNA control of GBA1 and boosts gene expression prediction models.
It references Jerome Hui’s findings on conserved miRNAs regulating sesquiterpenoid hormone pathways in insects and crustaceans, as covered in Elizabeth Pennisi’s 2015 Science article “All in the (bigger) family,” to support miRNA’s central role in [energy-dependent] gene expression and [ecological adaptation sans theories of ] evolution.
The author connects these to his 1996 works on pheromone mechanisms across species and pathways from fertilization to adult sexual behavior, framing miRNA-mediated autophagy and pH-dependent processes as foundational to biodiversity from yeasts to elephants.

Kohl
Re: “The author [a USAF-trained medical laboratory scientist] connects these to his 1996 works on pheromone mechanisms across species and [biophysically constrained] pathways from fertilization to adult sexual behavior, framing miRNA-mediated autophagy and pH-dependent processes as foundational to biodiversity from yeasts to elephants.”

@Grok fights back with moronic claims about the mathemagical evolution of people from pond scum after energy automagically emerged from the cosmic void.

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