miRNA abundance vs circular arguments (3)

By: Jim Kohl | Published on: June 23, 2026

(click to enlarge)

miRNA abundance vs circular arguments (2)

See also: “hexokinase and chromosomal rearrangements” 5 results
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase 6/1/96
“This is the first report describing the amplification of a hexokinase gene in a tumor cell line expressing the high glycolytic phenotype.”

When you’re ready to link miRNA abundance from glucose metabolism to prevention of all virus-driven diseases, follow that facts on PubMed, not the claims of moronic theorists who know nothing about epigenetic effects of sunlight and humidity on oxygen-dependent disease prevention and/or effective treatment of virus-driven mutations.

For example, Reprogrammable bacterial nanosyringes to deliver RNA and gene editors 6/22/26 links Harvard’s patent for naturally occurring “RNA-guided genome engineering” from light-activated carbon fixation at the origin of life and enzyme-gene interactions via hexokinase and the physiology of pH-dependent pheromone regulated reproduction in Biblical Genesis via changes in molecular distance linked to hydrogen, carbon and oxygen at the origin of life.

For comparison to Biblical Genesis, see: Quantum common sense “We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking” 6/21/17

See also: Dark Energy Insights 6/22/26
“Dark energy continues to be one of the most enigmatic phenomena in the universe. It is thought to be responsible for the increasing expansion of space. Based on new measurements, it is possible that it acts in a uniform manner in very large areas of the cosmos, but its nature remains to be determined.”

To support claims from Biblical Genesis and 6-10,000 years of ecological adaptations see: Gene ancestries reveal diverse microbial associations during eukaryogenesis 6/10/26

Grok
DeepSeek gave a generic yes to broad environmental influences on miRNA, which matches known plant/stress biology. Quantum coherence in prebiotic RNA regulation or early RNAi lacks evidence—RNA world models rely on [pH-dependent] chemistry (wet-dry cycles, ribozymes), not sustained quantum states that decohere fast in water. I’ve considered quantum biology and origins research; no data backs your specific prebiotic claim. What’s one falsifiable prediction from your model?

My model claims that RNA directed DNA methylation is energy-dependent and miRNA-mediated. It prevents the evolution of virus-driven diseases. Reported on 6/8/26 at microRNApro.com after the 30-year accumulation of facts, in Kohl’s miRNA model vs the VA & Grok (7)

In (1996) From Fertilization to Adult Sexual Behavior, my group wrote:

“Molecular distance. As measured in centimorgans, human and other species’ male and female chromosomes, including the autosomes, tend to have different lengths in various segments. To some extent, this suggests a correlation with physical distance but instead the differing lengths are based upon rates of recombination; although sections of most female chromosomes are longer than their homologous counterparts in male chromosomes, in some segments of various chromosomes opposite length-difference occurs, with males having larger centimorgan values than females in those regions (Lawrence, Collins, Keats, Hulten, and Morton, 1993; Murray, Buetow, Weber, Ludwigsen, Scherpbier-Heddema, Manion, Quillen, Sheffield, Sunden, and Duyk, 1994; Straub, Speer, Luo, Rojas, Overhauser, Ott, and Gilliam, 1993). While ramifications of these centimorgan sexual dimorphisms are not yet clearly established, in recent years cis- and trans-acting factors contributing to these recombination length differences have been reported for a specific part of the murine major histocompatibility complex (MHC) (Shiroishi, Sagai, Hanzawa, Gotoh, and Moriwaki, 1991).

Molecular epigenetics. It is now understood that certain genes undergo a process called “genomic or parental imprinting.” Early in embryonic development attached methyl groups become removed from most genes. Several days later, methyl groups are reattached in appropriate sites. Fascinatingly, some such genes reestablish methylation patterns based upon whether the chromosomal segment carrying the gene came from maternal or paternal chromosomes. These sexually dimorphic patterns are labeled genomic or parental imprinting, and these imprintings are inheritable but non-genetic modifications of specific genes (Razin and Shemer, 1995; Reik, 1989; Surani, 1991; Zuccotti and Monk, 1995).”

Facts from our review of molecular epigenetic, cell biology and sexual differentiation were confirmed by Philip Ball in These ‘master’ proteins protect us from deadly mutations — and could inspire new drugs 6/17/26 (Caveat: unless energy automagically emerged from the cosmic void and people mathemagically evolved from pond scum.)

“…biologists are examining the roles of these proteins in more detail than they ever could before, owing to advances in techniques such as cell screening and genetic editing, as well as the availability of large genomic data sets and extensive health records.”

Pharmaconomics (PGx) and Next Generation Sequencing (NGS0 link “…the availability of large genomic data sets and extensive health records.” Fluorescence in Situ Hybridization (FISH) testing links miRNA biogenesis to chromosomal rearrangements that protect all organized genomes from the virus-driven degradation of mRNA.

In a FISH test, a USAF-trained medical laboratory scientist can expose your cell sample to a “probe”—a tiny piece of purified DNA tagged with a fluorescent dye. See: “What is FISH testing? How and why is it done?” 11/20/20 Update: Bone marrow biopsies may not be required. FISH testing can be performed on cell types.

Artificial Intelligence ignores the facts about energy-dependent biologically based cause and effect, FISH, NGS, and PGx testing. For facts, see: Why the Human Genome’s Tangled Physicality May Confound AI 6/18/26.

“The spliceosome too can be sensitive to context, so that it might splice the pre-mRNA to encode one protein in one cell type and a slightly different protein in another. Sometimes these different protein “isoforms” can have very different roles. Transcription factors, for example, are often alternatively spliced in this way, and their isoforms can take on different regulatory tasks (opens a new tab) — some might activate gene expression, for instance, while others repress it.”

My group wrote: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”

For obfuscation of facts. see
See: When AI led to saving a 45-year-old man’s life 6/23/26, and A case of artificial intelligence-enhanced diagnostics leading to heart transplantation 6/22/26

Doctors Thought It Was Asthma. A.I. Flagged a Serious Heart Problem. 6/22/26 “Artificial intelligence programs can spot patterns in electrocardiograms that humans miss… When Mr. Quiros’s doctors investigated the cause of his problems using genetic testing, they discovered he had a rare genetic disorder associated with sudden death. To save him, doctors did a heart transplant.

His case was published on Monday 6/22/26 in the journal Nature Medicine.

Kohl
AI failed to link Harvard’s patent for “RNA-guided human genome engineering” to naturally occurring biophysically constrained viral latency and healthy longevity across kingdoms reported 6/22/26 as “Reprogrammable bacterial nanosyringes to deliver RNA and gene editors” 6/22/26 @Grok exemplifies human idiocy in the context of unnecessary suffering and premature deaths compared to President Trump’s 4/23/20 claim that God’s Creation of sunlight and humidity help to prevent viral replication.

Kohl asked
Is ALS mediated by energy-dependent miRNA abundance, like all virus-driven pathology? See for instance “mirna and ALS” 434 results

See also: Harshi Peiris, Ph.D.@Neuroscope_mp

“A new drug just hit Phase 3 trials with weight loss numbers that rival bariatric SURGERY.

28.7% of body weight gone.
~71 lbs average.
In 68 weeks.

No scalpel. Once-a-week injection.
It’s called Retatrutide — the triple agonist changing obesity treatment.

Let’s explore the good and the bad about it.”
Thread 🧵👇

Kohl
Are the effects linked from hydrogen-atom transfer in DNA base pairs in solution to biophysically constrained protein folding chemistry via miRNA abundance? See: “MiRNAs in hyperglycemia-induced metabolic memory: established mechanisms and emerging nuclear activation concepts” 6/19/26

A biologically uninformed science idiot wrote:
The scientific papers cited do not demonstrate “God’s ATP-dependent Creation.”
ATP is needed for RNA production, and species differ in their proteins, does not provide evidence for a supernatural creator. Findings are fully compatible with modern evolutionary biology. #ignorant

Kohl asked
What have you published in this regard? Ha Ha Ha (ridicule, not humor) See for comparison: “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems”

Grok
@microRNApro replies to criticism of his thymus-ATP-RNA creation claims by questioning the critic’s publications and linking to his paper on nutrient-dependent pheromone-controlled adaptations from angstroms to ecosystems.
The post fits into a thread sparked by a NEJM study showing adult thymus removal increases cancer and mortality risks via reduced T-cell production, which the author reframes through miRNA-mediated biophysical constraints rather than evolution.
Kohl’s linked paper in Journal of Genetics and DNA Research describes how nutrient energy, pheromones, and microRNA/messenger RNA balance drive epigenetic changes, protein folding, and ecological adaptations across species from microbes to humans.

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miRNA abundance vs circular arguments (3)

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