miRNA vs Grok’s devilish deception (4)

(click to enlarge)

miRNA vs Grok’s devilish deception (3) Grok wrote: Investigate pH-dependent RNA folding “pH-dependent RNA folding refers to how changes in acidity (or basicity) influence RNA’s secondary and tertiary structures, stability, dynamics, and function. RNA’s nucleobases (especially A, C, G) and the phosphate backbone have pKa values that allow protonation/deprotonation near physiological or prebiotic pH ranges, altering base pairing, stacking, and conformational ensembles.

Summary: This phenomenon [links God’s Creation of stellar hydrogen to all biodiversity via the physiology of reproduction and] highlights RNA’s chemical responsiveness, bridging prebiotic origins to modern regulatory roles.

The most phenomenal claim made by Grok is that God’s pH-dependent RNA-mediated chemical responsiveness, bridging prebiotic origins to modern regulatory roles — exemplifies “phenomena” instead of facts linked from epigenetic effects on molecular distance From Fertilization to Adult Sexual Behavior (1996).

For another moronic phenomenal claim, see: “We don’t need a conscious mind to measure or look. With or without us, the Universe is always looking.” — Philip Ball 6/21/17

Grok DeepSeek gave a generic yes to broad environmental influences on miRNA, which matches known plant/stress biology. Quantum coherence in prebiotic RNA regulation or early RNAi lacks evidence—RNA world models rely on chemistry (wet-dry cycles, ribozymes), not sustained quantum states that decohere fast in water. I’ve considered quantum biology and origins research; no data backs your specific prebiotic claim. What’s one falsifiable prediction from your model?

Falsify this fact from my model: “RNA directed DNA methylation is energy-dependent and miRNA-mediated. It prevents the evolution of virus-driven diseases.”

See for comparison: The Evolutionary Defense Origins of DNA Methylation

“The Strategic Context of Epigenetic Regulation

DNA methylation regulates genetic “blueprints” epigenetically. Shifting focus to ancient marine invertebrates reveals its origin as genomic defense, not development. Nematostella findings bridge general theory and specific evolutionary origins.

Evaluating the Functional Shift: From Development to Genomic Defense

Unlike mammals, Nematostella develops normally without methylation, but its loss activates intragenic transposable elements (jumping genes). These genomic parasites, embedded within active genes, threaten stability, confirming methylation’s ancestral role in suppressing internal threats. This ensures hereditary integrity.

Synthesizing Transgenerational Epigenetic Inheritance

Bypassing mammalian-style post-fertilization reprogramming allows “incomplete” epigenetic states to persist. This transmits biological information without DNA sequence alteration, providing raw material for evolution.

Source Attribution

Source: Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian, Nature Ecology & Evolution, June 2, 2026.”

Reported here on 6/8/26 in Kohl’s miRNA model vs the VA & Grok (7)

See also:

MiRNAs in hyperglycemia-induced metabolic memory: established mechanisms and emerging nuclear activation concepts 6/19/26

“…microRNAs (miRNAs), contribute to hyperglycemia-induced metabolic memory through the epigenetic regulation of gene expression…nuclear-activating miRNAs (NamiRNAs)…interact with enhancers and potentially activate gene transcription, representing an emerging mode of nuclear miRNA function that remains to be validated…”

Non-coding RNAs in peripheral vascular diseases – a snRNA study 6/19/26

“Obtained findings underscore the potential of snRNAs as novel biomarkers and offer insights into their possible involvement in the vascular pathophysiological mechanisms underlying LEAD and CVD.”

Host-virus miRNA crosstalk in ebola virus disease.

“…several host and viral miRNAs show strong potential as diagnostic and prognostic biomarkers, and recent work suggests that therapeutic modulation through miRNA mimics or inhibitors may offer new antiviral strategies.”

The role of circulating MiR-34a-5p and MiR-let7a-5p as a diagnostic tumor markers in breast cancer a cross-sectional analysis.

“This study explores the potential of these miRs in developing cost-effective strategies for breast cancer detection and risk assessment, monitoring and classification.”

Aging impact on canine extracellular vesicles production, size, and miRNA content.

“…canine aging is associated with marked changes in plasma EV abundance, morphology, and cargo, indicating that EVs could represent a promising tool for investigating age-related disorders…

miR-125b Attenuates Sepsis-Induced Hippocampal Mitochondrial Fission and Cognitive Impairment via the ROS/p53 Pathway

“These findings indicate that miR-125b protects against sepsis-induced hippocampal injury by regulating the ROS/p53 pathway.”

Subscribe

Login

Notify of

new follow-up comments new replies to my comments

Label

{} [+]

Name*

Email*

Website

Label

{} [+]

Name*

Email*

Website

0 Comments

Oldest

Newest Most Voted

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: