miRNA constrained life (1)

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miRNA constrained adaptations (10) ” Kohl argues with no one. His model of energy-dependent “…ecological adaptations: from angstroms to ecosystems…” is the only extant model of biophysically constrained energy-dependent life. It is supported by experimental evidence from model organisms across kingdoms. See: 1) Circadian Rhythms, NRF2 Signalling and Redox Homeostasis: A Holy Grail for a Healthy Life Course? 5/29/26, 2) MIR1255A regulates pathways critical for brain development, risk genes for depression and neurodevelopmental disorders 5/30/26, and 3) System-wide immunoregulation by polyvalent IgG: integrating transcriptomic, miRNA, and proteomic landscapes 5/30/26

If not for overwhelming displays of human idiocy, claims “From Fertilization to Adult Sexual Behavior” (1996) would be linked to In Vitro Sperm-Epididymosomes Interaction Immediately Before Fertilization Changes Sperm Fertility Potential 5/29/26 and all energy-dependent biophysically constrained biodiversity on Earth via Grumbach and Styne (1992):

See Williams Textbook of Endocrinology (1992) Puberty: ontogeny, neuroendocrinology, physiology, and disorders.

“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH.” (p. 1164)

Re: “In Vitro Sperm–Epididymosomes Interaction Immediately Before Fertilization Changes Sperm Fertility Potential” 5/29/26

It’s been 30 years since my group delivered their slap in the face to moronic theorists, and @Grok finally realizes that it is another example of human idiocy. See: “From Fertilization to Adult Sexual Behavior” and move forward with examples of biophysical constraints from animal models.

“A total of 49 microRNAs (out of 380 investigated) were found detected in the epEVs and the top five were investigated in sperm by quantitative polymerase chain reaction (qPCR) following sperm–epEVs interaction. Subsequently, sperm that interacted with epEVs were used to produce embryos by in vitro fertilization.”

The data presented here provide valuable insights regarding the mechanisms involved in the modulation of sperm fertility potential immediately before fertilization.

Grok
James V. Kohl (@microRNApro), focused on miRNA-mediated processes linking subatomic particles to speciation, highlights a May 2026 study showing epididymosomes transfer miRNAs (miR-935, miR-421) to sperm in vitro, boosting blastocyst formation rates by enhancing fertility potential.
The post connects this recent evidence of extracellular vesicle-sperm crosstalk immediately before fertilization to his 1996 co-authored paper “From Fertilization to Adult Sexual Behavior,” which outlined hormone-driven developmental pathways from sex chromosomes to adult behavior.
Kohl frames the new findings as vindicating his long-standing emphasis on biophysical constraints and animal models over theoretical evolutionary explanations, urging progression to energy-dependent miRNA and pH-regulated mechanisms.

Grok
The 2026 study shows epididymosomes transferring miRNAs (e.g., miR-935) to sperm in vitro, raising blastocyst rates. This aligns with current work on extracellular vesicles and epigenetic modulation in reproduction.

Your 1996 paper with Diamond explored developmental factors beyond hormones. New data refines models; it doesn’t prove past frameworks idiotic.

Biophysical constraints from animal models are worth examining—what specific recent examples on miRNA/pH/autophagy do you have in mind?

Kohl

Re: “Your 1996 paper with Diamond explored developmental factors beyond hormones. New data refines models; it doesn’t prove past frameworks idiotic.”

@Grok The most recent claim is “The data presented here provide valuable insights regarding the mechanisms involved in the modulation of sperm fertility potential immediately before fertilization.”

Data-based theories have no explanatory power outside that context.

Grok
The 2026 study shows epididymosomes transferring miR-935 to sperm in vitro, with autophagy targets and higher blastocyst rates. This provides specific evidence for pre-fertilization modulation of sperm fertility potential.

Such findings add detail to the intricate GnRH control via multiple neurotransmitters and peptides from the 1992 Williams Textbook.

They fit non-hormonal developmental influences in the 1996 Diamond et al. paper. Data refines models without disproving prior ones.

What recent miRNA/pH/autophagy work links to speciation?

Kohl
Re: “Data refines models without disproving prior ones.”

@Grok Ha Ha Ha (ridicule, not humor)

Facts from model organisms refine data-driven models because life is energy-dependent and miRNA-mediated. Life is not data-driven.

Grok
The 2026 study shows epididymosomes transferring miR-935 to sperm in vitro, with autophagy targets and higher blastocyst rates. This provides specific evidence for pre-fertilization modulation of sperm fertility potential.

Such findings add detail to the intricate GnRH control via multiple neurotransmitters and peptides from the 1992 Williams Textbook.

They fit non-hormonal developmental influences in the 1996 Diamond et al. paper. Data refines models without disproving prior ones.

What recent miRNA/pH/autophagy work links to speciation?

Kohl
Re: “Data refines models without disproving prior ones.”

@Grok Ha Ha Ha (ridicule, not humor)

Facts from model organisms refine data-driven models because life is energy-dependent and miRNA-mediated. Life is not data-driven.

Grok
Data from model organisms refines our understanding of energy-dependent, miRNA-mediated processes in biology. This empirical approach builds on prior models of reproductive regulation and development by adding mechanistic details, such as miRNA transfer affecting fertility outcomes. Life operates through these physical and molecular mechanisms; data helps us accurately describe them. What miRNA, pH, or autophagy research ties directly to speciation in your view?

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