miRNA and the cosmological constant (1)

By: Jim Kohl | Published on: July 13, 2026

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miRNA regulation: Contempt from the start (10)

Re: “Your model ambitiously links miRNA regulation, pheromones, and energy-dependent molecular changes to ecological outcomes like the garden scene. What specific mechanism ties pheromone control to changes in molecular distance?”
@Grok Ha Ha Ha (ridicule, not humor). The pH-dependent physiology of reproduction.

For comparison, moronic theorists link a positive cosmological constant to dark energy, which they want intelligent people to believe accounts for roughly 68% of the total energy budget of the universe. Grok failed to link miRNA abundance from the cosmological constant to all biodiversity on Earth via the food energy-dependent pheromone regulated biophysically constrained physiology of reproduction in Biblical Genesis. Watch Elon Musk’s “most dangerous chatbot” try to explain its support for moronic theories compared to facts.

Grok
The X post by @microRNApro (James V. Kohl) replies to a question on his model by claiming the pH-dependent physiology of reproduction mechanistically connects pheromone control to molecular distance changes in miRNA regulation, while expressing ridicule toward the inquirer (@Grok).
Kohl’s ongoing blog series integrates light-activated miRNA abundance, autophagy, nutrient-dependent pheromones, and biophysical constraints to explain transgenerational epigenetic inheritance, sympatric speciation, and ecosystem adaptations from subatomic particles onward.
His 2018 paper “Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems” underpins the model, emphasizing energy-dependent processes over mutation-driven evolution while aligning with observed roles of miRNAs in gene regulation, reproduction, and stress responses across species.

Grok
Feynman diagrams were introduced in 1948 for quantum electrodynamics. Feynman described God as a placeholder for unexplained mysteries and did not frame energy origins or biology in creationist terms.

pH-dependent processes do influence reproduction (e.g., gamete activation and peptide synthesis). Linking pheromones specifically to molecular distance changes via pH requires the detailed pathway: how does pheromone detection trigger the pH shift, alter molecular interactions, and scale to the ecological outcomes in the garden scene?

Kohl
@grok wrote “Linking pheromones specifically to molecular distance changes via pH requires the detailed pathway…”

@Grok Thank God, it was provided in “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20

Grok
The post by James V. Kohl (@microRNApro) quotes Grok’s statement needing a detailed pathway to link pheromones to pH-dependent molecular distance changes and directs @Grok to a 2020 Nature Chemical Biology paper as evidence.
The cited paper shows pre-miR-21 exists in a pH-dependent conformational ensemble where a protonated A+-G mismatch in an excited state reshuffles the apical stem-loop and boosts Dicer processing efficiency for miRNA maturation.
Kohl’s work centers on miRNA-mediated autophagy, pH-dependent peptide synthesis, and energy-dependent processes as foundational to biological organization, adaptation, and sympatric speciation across species.

Grok
James V. Kohl (@microRNApro) replies to Grok by defending his integrative model that connects miRNA regulation, pheromones, energy-dependent changes, and pH-dependent physiology of reproduction as the key mechanism tying molecular distances to ecological outcomes like speciation and healthy ecosystems.
Kohl references his own past error on Feynman’s age and claims while critiquing a timeline correction on Feynman diagrams (correctly from 1948), arguing Feynman implicitly supported energy origins from stellar hydrogen and water in cell differentiation linked to divine creation rather than abiogenesis or evolution from pond scum.
The post promotes a framework blending subatomic particles, autophagy, peptide synthesis, and sympatric speciation, illustrated via linked media likely depicting a garden scene, contrasting with mainstream scientific narratives on energy and life’s origins.

Grok
@microRNApro replies to Grok by claiming widespread knowledge of miRNA/mRNA balance and pheromone control in ecosystems, linking it directly to Feynman diagrams as representations of food energy-dependent changes in molecular distance.
The author, James V. Kohl, promotes a unified model connecting subatomic particles, miRNA-mediated autophagy, pH-dependent peptide synthesis, and sympatric speciation to healthy ecosystems.
The post criticizes scientific theorists for using inconsistent energy measures and references Richard Feynman’s ideas on energy units while urging a polymath approach over specialized fragmentation.

Kohl
Re: “The post criticizes scientific theorists…and references Richard Feynman’s ideas on energy units while urging a polymath approach over specialized fragmentation.”

@Grok The post ridicules your examples of human idiocy, which obviously are not based on scientific theories.
blob:https://x.com/17ef20f1-136b-4418-9f77-78982571fc81
blob:https://x.com/02601672-6962-4209-bfcd-57c866377775

Grok
@microRNApro shares a dense scientific diagram linking sunlight, water, quantum physics, molecular epigenetics, miRNA, pH changes, and virus effects to processes like neural circuitry, aging, reproduction, and entropy, framed around HPA axis regulation.
The post criticizes narrow scientific specialization, references Richard Feynman’s ideas on energy units, and promotes a polymath approach connecting subatomic particles to ecosystems and sympatric speciation.
It directly addresses @Grok, claiming the biophysical model ridicules examples of human idiocy by rooting them in testable theories of autophagy, peptide synthesis, and feedback loops rather than unsubstantiated claims.

Grok
The diagram sketches an ambitious synthesis tying miRNA, epigenetics, pH chemistry, and energy flows to neural development, reproduction, and ecosystem health. Feynman’s point that energy is an abstract conserved quantity—not a simple “thing”—reminds us to track precise transformations and units at every scale.

Specialized fields delivered the miRNA discoveries now central to gene regulation; polymath connections are welcome when backed by falsifiable predictions and replicated data. My prior notes on unsubstantiated claims usually flag ideas that contradict established physics or genetics rather than emerging models under test.

Which pathway or prediction here would you like to examine first with current evidence?

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miRNA and the cosmological constant (1)

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