Hormones signal miRNA responses (4)

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Hormones signal miRNA responses (3)

“Enhanced in vitro anticancer activity of a platinum-Mesalazine complex against colorectal cancer cells apoptotic modulation and evidence of non-intercalative DNA binding, and 115 results linked to this search for pH-dependent non-intercalative DNA binding, which occurs when molecules interact with the exterior of the structure and attach to double-stranded DNA without slipping between adjacent base pairs.

Instead of disrupting the stacking of the double helix, these molecular agents typically act through electrostatic attraction, hydrogen bonding, or fit snugly into the major or minor grooves.

No experimental evidence from model organisms links them to mathemagical models of mutation-driven evolution after energy automagically emerged from the cosmic void ~14.2 billion years ago.”

But see: Key human defenses against pathogens were forged billions of years ago in microbial battles with viruses. 5/21/26

No experimental evidence from model organisms supports this moronic claim.

Most of the hydrogen in your body was not created inside a star. It formed during the Big Bang, roughly 13.8 billion years ago, when the early universe produced vast amounts of hydrogen along with helium and tiny amounts of other light elements — a process called Big Bang nucleosynthesis, occurring within the first few minutes of the universe’s existence.

More than 1800 human hemoglobin variants link God’s Creation of stellar hydrogen to 6-10,000 years of nutrient-dependent pheromone regulated transgenerational epigenetic inheritance of all oxygen-dependent morphological and behavioral phenotypes found in carbon-based life.

Our brains evolved to survive, not to find truth 11/4/25

The truth will set you free. Our brains exemplify nutrient-dependent pheromone regulated ecological adaptations. See: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018).

For comparison to the facts, see: An analysis of fossil mammals suggests that Mexico served as a long-term evolutionary “holding pen” where North American species adapted and diversified for millions of years before sweeping into South America 2.8 million years ago.

The findings in Science clarify the timing of one of Earth’s most consequential migrations and may help explain why North American mammals were more successful migrants than those from South America.

Fixation of EDAR V370A in populations from East Asia to North America links 5000 years of ecological adaptation in the mouse-to-human model of morphological and behavioral phenotypes via natural selection for biophysically constrained codon optimality.

Grok

James V. Kohl (@microRNApro) advances his longstanding “atoms to ecosystems” model, which ties hormone signaling to miRNA biogenesis, pH-dependent proton switches in pre-miR-21 maturation, and natural proton gradients to autophagy, cell differentiation, viral latency, and sympatric speciation.The post integrates these molecular claims with 2020s U.S. policy by linking Trump’s sunlight/humidity coronavirus comments, RFK Jr.’s peptide therapy advocacy, GLP-1 agonists for metabolic diseases, and recent military testosterone testing proposals.Grok’s reply in the thread affirms experimentally supported elements like bidirectional hormone-miRNA regulation and NMR-documented pH protonation effects, while distinguishing them from the author’s wider synthesis spanning subatomic physics to interpretive claims on evolution and Genesis.

Grok

The post discusses pH-dependent non-intercalative DNA binding by a platinum-Mesalazine complex in colorectal cancer cells, highlighting mechanisms like electrostatic attraction, hydrogen bonding, and groove binding rather than base pair intercalation.

Author James V. Kohl connects this to his model of hormone-regulated miRNA responses, citing evidence from NMR studies on miR-21 maturation and proton gradients, while arguing no model organism data links such processes to mutation-driven evolution.

Kohl’s ongoing work frames miRNA-mediated autophagy and peptide synthesis as foundational to sympatric speciation and ecosystems, integrating recent studies on stress, metabolic diseases, and environmental factors into a unified alternative to mainstream evolutionary narratives.

Re: More mainstream evolutionary narratives

“stealing” genes from other organisms. That ability has allowed them to go 40 million years without sex, once leading biologist John Maynard Smith to call them an “evolutionary scandal.”

Research from 2024 may explain how this animal got to where it is today, finding that some bdelloids can protect themselves against infection using chemical “recipes” pilfered from bacteria.

40 million years without sex? Was that before or after nutrient dependent pheromone regulated sexual differentiation of yeasts was linked to cancer-free African elephants via Biblical Genesis.

For comparison, Abdulrahman Mohamed El-Sayed is an epidemiologist who was the director of the Department of Health, Human, and Veterans Services of Wayne County, Michigan from 2023 to 2025

Is he is the author of this challenge to use of Grok AI’s algorithms to promote moronic theories linked from the automagical emergence of energy from the cosmic void to the mathemagical evolution of people from pond scum?

See: “Medical Algorithms Need Better Regulation” 10/7/21

“Under current law, medical algorithms are classified as medical devices and can be approved with the 510(k)-approval process.”

If so, why did that not stop the VA’s medical malpractice revealed by the Secretary of War and Secretary of Health and Human Services, which was revealed by their connections to reports on peptide therapies that linked glucose metabolism to stress via testing for testosterone, PGx testing, NGS testing and FISH testing for chromosomal rearrangements linked to medication errors, unnecessary suffering and premature deaths?

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