miRNA mechanisms vs metaphors (3)

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miRNA mechanisms vs metaphors (2)“

“James V. Kohl’s caveat criticizes any separation of physics from quantum coherence in organized biological systems, consistent with his focus on miRNA-mediated autophagy, pH-dependent peptide synthesis, pheromones, and sympatric speciation.”

[He contrasts the cancer-free African elephant model organism with virus-driven extinction of Angel Trumpets in the wild, in an attempt to convey the facts of life to @Grok]

Kohl
“Empirical bridges require specific data.”

@Grok Did WHO lead you do make that moronic claim?

Integration of data with facts is required.

For pattern recognition, see: “MicroRNAs organize intrinsic variation into stem cell states. 3/5/20 “naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.”

Chakraborty (2000) linked cosmological constants from quantum coherence to miRNA-mediated coherently organized biology. So did President Trump on 4/23/20, and Demongeot and @CaudeHenrion in “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life” 4/25/20 See also: “Visualizing a protonated RNA state that modulates microRNA-21 maturation” 10/26/20

Because life is pH-dependent not data-driven, your claim “Empirical bridges require specific data” exemplifies human idiocy.

Grok
@microRNApro criticizes Grok for claiming empirical bridges need specific data, calling it moronic and potentially WHO-influenced while arguing biology is fundamentally pH-dependent through miRNA organization rather than purely data-driven.
The post links a 2020 PNAS paper showing miRNAs coordinate intrinsic cell variation into distinct stem cell states with a Demongeot and Henrion-Caude paper on a 22-nucleotide RNA ring relic from life’s origin and quantum coherence concepts.
Author James V. Kohl promotes theories connecting miRNA-mediated autophagy, pH-dependent processes, and subatomic particles to sympatric speciation and healthy ecosystems.

Kohl
Re: “James V. Kohl promotes theories connecting miRNA-mediated autophagy, pH-dependent processes, and subatomic particles to sympatric speciation and healthy ecosystems.”

@Grok Ha Ha Ha (ridicule, not humor) On 7/15/26 @SecWar linked James V. Kohl’s model from PGx, NGS, FISH, and testosterone testing to mental and physical health of soldiers 30+ (and to all US veterans via sex differences in yeasts to mammals.) blob:https://x.com/175eea58-9945-4858-be64-94d50890053b

Grok
The July 15 SecWar announcement authorized annual testosterone screening for troops 30+ based on age-related decline and readiness needs, with voluntary treatment. No reference exists to miRNA models, PGx/NGS/FISH integration with sympatric speciation, or subatomic links. Those broader claims lack experimental consensus. The diagram maps proposed feedbacks; clinical programs rest on separate hormone and pharmacogenomic evidence.

Re: Separate hormone and pharmacogenomic evidence.

Grok My mentors, Bruce S. McEwen, Robert L. Moss and others helped to ensure I did not make the mistake made by moronic theorists who separated hormone and pharmacogenomic evidence. They told me to “start with gene activation in neurosecretory cells, not gene-centric theories.” See why:

Williams Textbook of Endocrinology (1992) Puberty: ontogeny, neuroendocrinology, physiology, and disorders.
“…noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH.” (p. 1164)

GnRH pulse frequency and amplitude link epigenetic effects of food odors and pheromones to the physiology of reproduction in all jawed vertebrates. My publication history followed the lead of other intelligent serious scientists who started with gene activation in GnRH neurosecretory neurons, not moronic gene-centric theories.

Grok
No, that follows standard scientific method, not WHO. Specific data are required to empirically link claims across scales. The 2020 PNAS paper shows miRNAs organize stem-cell variation into states. The 22-nt RNA ring paper is a computational origin-of-life hypothesis. pH-dependent RNA states that alter miR-21 maturation are experimentally measured. Data establish the biology, including its pH sensitivity.

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