miRNA facts vs AI’s data (9)

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miRNA facts vs AI’s data (8)

The broader views link energy-dependent miRNA abundance at the origin of life from PGx testing to prevention of virus-driven pathology and medical malpractice via Next Generation Sequencing (NGS), and everything known about chromosomal rearrangements to biodiversity whether or not it wins the 2026 Nobel Prize in Chemistry.

See my group’s review of biophysically constrained virus-driven pathology: From Fertilization to Adult Sexual Behavior (1996) and the aforementioned Identification of an atypical microRNA with sequence variation in the silkworm Bombyx mori 10/6/26

Intelligent serious scientists linked the diet-driven pheromone regulated metamorphosis of caterpillars to moths in Merian (1679) and in Darwin (1859) via his “conditions of life.”

@Grok’s data-driven nonsense fails to link energy-dependent miRNA-mediated processes to autophagy, peptide synthesis, sympatric speciation, and ecosystem health via my model.

Grok

I am checking primary descriptions of Denis Noble’s positions so the comparison with Kohl stays accurate.Denis Noble and James Kohl both criticize gene-centric neo-Darwinism and stress higher-level biological constraints, but they differ sharply in training, evidence base, scope, and standing in the scientific literature.Noble is a career physiologist (former Burdon Sanderson Professor of Cardiovascular Physiology at Oxford, FRS) whose core technical work is the mathematical modeling of the heart. His 1960s models were among the first to apply Hodgkin–Huxley equations to the cardiac action potential and helped establish computational cardiac electrophysiology. From books such as The Music of Life (2006) and Dance to the Tune of Life (2016) he developed the principle of biological relativity: there is no privileged level of causation, so genes are passive templates whose activity is constrained by cellular, tissue, and organismal networks. He argues that the Central Dogma and the Modern Synthesis understate downward causation, epigenetic inheritance, and the harnessing of molecular stochasticity by higher-level systems. These claims appear in journals such as Journal of Experimental Biology and Interface Focus and are associated with the “Third Way of Evolution” project; they remain outside mainstream evolutionary biology and have drawn detailed criticism for mischaracterizing contemporary population genetics.Kohl is an independent researcher (medical laboratory scientist) whose published work began with a narrower claim. The 1996 paper with Diamond and Binstock in Hormones and Behavior argued that the classic gonad–hormone–behavior model of mammalian sexual development is incomplete because nongonadal genetic, imprinting, and environmental factors also contribute. His later papers in Socioaffective Neuroscience & Psychology (2012, 2013) propose that nutrient-derived chemicals and pheromones alter the miRNA/mRNA balance and GnRH-neuron activity, thereby controlling hormone pulsatility and adaptive behavior from microbes to mammals. Subsequent writings extend this into an energy-dependent (ATP- and pH-linked) miRNA framework that he presents as the primary constraint on peptide synthesis, autophagy, chromosomal stability, virus-driven pathology, sympatric speciation, and ecosystem health, often rejecting mutation-selection as a significant causal process.The practical differences are therefore these. Noble’s critique is framed as a multi-scale systems principle grounded in cardiac modeling and mathematical boundary conditions; it retains standard molecular mechanisms while denying genes exclusive causal privilege. Kohl’s thesis is a specific chemical-ecology pathway (nutrients and pheromones acting through miRNA balance and GnRH) that he later generalizes to an encompassing energy-and-miRNA account of origins, pathology, and biodiversity. Noble’s evolutionary arguments are published and debated within physiology and systems-biology venues; Kohl’s broader claims circulate mainly through his own sites and social-media series and have received direct published criticism for over-extension. Both reject a purely gene-centered view, but only Noble’s position is rooted in a large body of primary physiological modeling.

Re: Kohl’s broader claims circulate mainly through his own sites and social-media series and have received direct published criticism for over-extension. Both reject a purely gene-centered view, but only Noble’s position is rooted in a large body of primary physiological modeling.

Noble and Kohl’s shared positions pit the pseudoscientific nonsense of the critique of Kohl’s model by undergraduate nursing student Andrew Jones, and olfactory researcher Richard Doty against claims from 2,783 results in today’s search of PubMed for indexed articles that mention mirna and heart failure

See for comparison: Announcement of the 2026 Nobel Prize in Chemistry Wednesday, October 7, 2026, at 11:45 CEST (5:45 a.m. EDT) at the earliest.

Grok

Sequencing-by-synthesis draws energy from dNTP triphosphate bonds in polymerase reactions. miRNAs regulate gene expression across kingdoms and are profiled by NGS, yet the Wolf Prize NGS platforms show no documented miRNA mediation or ties to stellar energy or African elephant differentiation. Nobel Chemistry 2026 went to Kagan and Soai for asymmetric synthesis. Brugmansia (angel’s trumpets) are IUCN Extinct in the Wild, persisting only in cultivation.

Kohl

Re:” no documented miRNA mediation or ties to stellar energy or African elephant differentiation”
@Grok Awarded to Henri Kagan and Kenso Soai https://www.youtube.com/watch?v=a9Bhx9wEt8U for God’s Creation of chirality (Ben Feringa’s 2016 award) and achiral glycine linked from olfactory receptors to all biodiversity on Earth.

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